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Using two separate drugs to shed pounds can be very effective you will find combinations before the FDA now awaiting approval. When dealing with weight loss and the those who go through it you should err on the side of caution and allow FDA do its job and demand some investigation be done in order that the public understands the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies will be in business to generate income and that they would say everything to keep people on the medications. Researchers found out that participants taking this drug for any year, dropped a few pounds within 4 weeks and have kept the weight off throughout the 56 weeks from the study. Contrave is a combination from the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs that are made up of more than one active ingredient, which might make them far better and safer. Combo-pilling could be the newest fad or even better the newest in the future under scrutiny and so it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills has become popular will be the fact that by right now there aren't any long term prescription diet pills that have been licensed by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be licensed by the FDA. Seizures are a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug also can raise hypertension and heart rate, and must not be used in those with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure and heartbeat and must stop used in patients with uncontrolled high blood pressure, and also by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients having a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients for the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking. Acamprosate also functions eliminate the wish to drink by eliminating the the cravings for alcohol consumption. The major difference between Naltrexone and Acamprosate is the fact that Acamprosate isn't yet obtainable in the United States. While it has become widely studied in Europe the complete chemical reason that it works remains to be unknown. It is belief that it disrupts receptors within the brain which process glutamate, which in place alters the best way ones body reacts to alcohol intake. Several of the European research has revealed a lot of promise with Acamprosate because some of the patients had a nearly double effectiveness for staying sober.