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We will get through most situations as long as we can preserve the lives from the ones we like. Using two separate drugs to lose weight can be very effective you can find combinations before the FDA now awaiting approval. When dealing with weight-loss and the people who go through it you need to err assisting caution and let the FDA do its job and demand some investigation be done so that the public understands the side effects and hazards of the medications before we take them. Keep in mind that drug companies have been in business to generate money and that they would say anything to keep people on their medications. Researchers found that participants taking this drug for any year, lost excess weight within 4 weeks and have kept the weight off throughout the 56 weeks with the study. Contrave is a combination in the drugs naltrexone and bupropion, which generally seems to reflect a brand new trend of weight-loss drugs which can be made up of more than one active ingredient, that might make them more effective and safer. Combo-pilling may be the newest fad or even better the newest into the future under scrutiny and so it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills has become popular may be the fact that by right now there are not any long term prescription weight loss supplements that have been approved by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be licensed by the FDA. Seizures can be a side effect with Contrave and must not be taken in people who have seizure disorders. The drug can also raise blood pressure level and heartrate, and must not be used in people with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise hypertension and pulse rate and must not used in patients with uncontrolled high blood pressure levels, along with by you are not heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients which has a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients towards the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking. From a psychiatric standpoint, evidence points too the ordinary neural mechanism for goal-directed behavior has become hijacked by the addiction, and malfunctions in such a way that its ordinary functions are exaggerated and fixated on its object. An object generates a stimulus and also the person engages in a "goal-directed behavioral response" that creates a "natural high"(Bostwick & Bucci, 2008).